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Rheumatoid arthritis (RA) is a chronic autoimmune multisystemic inflammatory disease which affects many . Etiology is unknown but is probably multifactorial. The epidemiology of rheumatoid arthritis.
Rheumatoid arthritis (RA) is a chronic autoimmune multisystemic inflammatory disease which affects many organs but predominantly attacks the synovial tissues and joints. It is generally considered that a genetic predisposition (HLA-DR B1 which is the most common allele of HLA-DR4 involved in RA) and an environmental trigger (Epstein-Barr virus postulated as a possible antigen, but not proven) lead to an autoimmune response that is directed against synovial structures and other organs.
Joints Noninfective arthritis Rheumatoid arthritis. Morning stiffness, arthritis in 3+ joint areas, arthritis in hand joints, symmetric arthritis, rheumatoid nodules, rheumatoid factor, typical radiographic changes. Author: Vijay Shankar, . Topic Completed: 1 May 2013. Revised: 30 September 2019. 80% have IgM autoantibodies to Fc portion of IgG (rheumatoid factor), which is not sensitive or specific; synovial fluid has increased neutrophils (particularly in acute stage), increased protein, low mucin. Other antibodies include antikeratin antibody (specific, not sensitive), antiperinuclear factor, anti rheumatoid arthritis associated nuclear antigen (RANA).
Rheumatoid arthritis, chronic, frequently progressive disease in which inflammatory changes occur throughout the connective tissues of the body
Rheumatoid arthritis, chronic, frequently progressive disease in which inflammatory changes occur throughout the connective tissues of the body. Inflammation and thickening of the synovial membranes (the sacs holding the fluid that lubricates the joints) cause irreversible damage to the joint. The most useful medications in relieving the pain and disability of rheumatoid arthritis are aspirin and ibuprofen, which have anti-inflammatory properties. If large doses of these are not sufficient, small doses of corticosteroids such as prednisone may be used. Disease-modifying antirheumatic drugs (DMARDs) also may be prescribed to slow the course of the disease.
Gardner, D. L. (1972) The Pathology of Rheumatoid Arthritis. Edward Arnold, London. Scott, D. G. Bacon, P. A. and Tribe, C. R. (1981) Systemic rheumatoid vasculitis: a clinical and laboratory study of 50 cases. Medicine, 60, 285–97. CrossRefGoogle Scholar. Authors and Affiliations.
Rheumatoid arthritis is characterised by persistent synovitis, systemic inflammation, and autoantibodies (particularly to rheumatoid factor and citrullinated peptide). 50% of the risk for development of rheumatoid arthritis is attributable to genetic factors. Smoking is the main environmental risk.
Practice & QualityClinical SupportClinical Practice Arthritis. Rheumatoid Arthritis. 2019 American College of Rheumatology Guideline for the Management of Rheumatoid Arthritis (final publication of updated guideline anticipated in late 2019, early 2020). Updated Guideline for the Management of Rheumatoid Arthritis Project Plan. 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Documents related to this guideline: Appendix 1 - Evidence Report.
GARDNER DL: The Pathology of Rheuma -toid Arthritis, London, Edward Arnold, 1972: 7-38. 15. GRIMLEY PM, SOKOLOFF L: Synovial giant cells in rheumatoid arthritis. Am J Pathol 1966; 49: 931-54. 16. MUIRDEN KD, SENATOR GB: Iron in the synovial membrane in rheumatoid arthritis and other joint diseases.
Gardner LI MacLachlan EA Berman H 1952 Effect of potassium deficiency on carbon dioxide, cation, and phosphate content of muscle. Journal of General Physiology 36; 153-159.
There is an increasing number of rheumatoid patients who get septic arthritis. The clinical picture of septic arthritis is different in immunocompromised patients like patients with rheumatoid arthritis. Chronic use of steroids is one of the important predisposing factors.